Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is São Tomé (50% of total searches to São Tomé and Príncipe). The next most popular destination is Bom Bom Island (50%).
Based on KAYAK hotel searches, the most popular region to stay in São Tomé and Príncipe is Príncipe. Sao Tome and {1} are also very popular.